TRPV1 CHANNELS IN THE CENTRAL NERVOUS SYSTEM AS DRUG TARGETS

TRPV1 Channels in the Central Nervous System as Drug Targets

TRPV1 channels are polymodal cation channels located predominantly on primary afferent neurons that are activated by inflammatory mediators, capsaicin (the active component in chili peppers), and noxious heat.TRPV1 channel antagonists are potential new here analgesic agents, but their development has been hindered by the finding that they also prod

read more



Only three out of ten women received adequate postnatal care in sub-Saharan Africa: evidence from 20 countries demographic and health surveys (2015–2022)

Abstract Background The magnitude of maternal and neonatal death and morbidity during the postnatal period remains too high.In contrast to the decline in global mortality rates, maternal and neonatal deaths continue to occur at the highest rate in sub-Saharan Africa.Appropriate care during the postpartum period is vital to prevent neonatal and mate

read more

The Characterization of Pastures by Grazing Cycle and Evaluation of Supplementation with Agro-Industry Co-Products on the Performance of Buffaloes in the Humid Tropics

The objective was to characterize the pastures by grazing cycle, as well as to evaluate the performance of buffaloes in intensive rotational grazing in a silvopastoral system in the eastern Amazon supplemented with agro-industry co-products in order to characterize the grazing cycles, the composition of folk rivet sweat the fractions, and the carca

read more