TRPV1 Channels in the Central Nervous System as Drug Targets
TRPV1 channels are polymodal cation channels located predominantly on primary afferent neurons that are activated by inflammatory mediators, capsaicin (the active component in chili peppers), and noxious heat.TRPV1 channel antagonists are potential new here analgesic agents, but their development has been hindered by the finding that they also prod